||Human activity in this area has been traced to prehistoric eras. Native American tribes once roamed this land with the buffalo, deer, turkey, mountain lion, and black bear. Among the first recorded ventures into the canyon were the Military Road survey and the forty-niner mail route of 1849. The Military Road was used by the Butterfield Stage-Overland Mail route from 1858 to 1861. The canyon was named for the mulberry trees that grew along the largest creek.
Cattle ranchers began to use the canyon in the 1870s. The last herds of buffalo passed through Mulberry Canyon in 1878 just before pioneer families began to build communities. In 1879 settlers planted maize, corn, and wheat; the first cotton was planted in 1886. The last black bear lived as a pet on the Brown Ranch in the 1880s.
Over half a dozen small communities sprang up in the canyon. Ten churches and ten schools have served the area, which at its peak had a population of 500. The earliest marked grave in White Church Cemetery is dated 1883. Nubia, the only town, had a post office until 1917. The last store closed in 1946.
In 1997, descendants of the pioneer settlers still occupied much of Mulberry Canyon. (1997)